BDBM698893 (4-((R)-3-hydroxy-3-methylpiperidin-1-yl)-2-((1- (((S)-3-(hydroxymethyl)piperidin-1- yl)methyl)cyclopropyl)methoxy)-5,7-dihydro- 6H-pyrrolo[3,4-d]pyrimidin-6-yl)(3-hydroxy-8- iodonaphthalen-1-yl)methanone::US20240317759, Example 102

SMILES C[C@@]1(O)CCCN(C1)c1nc(OCC2(CN3CCC[C@H](CO)C3)CC2)nc2CN(Cc12)C(=O)c1cc(O)cc2cccc(I)c12

InChI Key InChIKey=INZIONSXEIGDOQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 698893   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM698893((4-((R)-3-hydroxy-3-methylpiperidin-1-yl)-2-((1- (...)
Affinity DataIC50: 1.20E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM698893((4-((R)-3-hydroxy-3-methylpiperidin-1-yl)-2-((1- (...)
Affinity DataIC50: 1.90E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetGTPase KRas [G12V]/Son of sevenless homolog 1 [564-1049](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM698893((4-((R)-3-hydroxy-3-methylpiperidin-1-yl)-2-((1- (...)
Affinity DataIC50: 2.10E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent