BDBM698925 (R)-(2-((1-((dimethyl- amino)methyl)cyclo- propyl)methoxy)- 4-(3-hydroxy-3- methylpiperidin-1-yl)-5,7- dihydro-6H-pyrrolo[3,4- d]pyrimidin-6-yl)(8- ethynyl-3- hydroxynaphthalen-1- yl)methanone::US20240317759, Example 134

SMILES CN(C)CC1(COc2nc3CN(Cc3c(n2)N2CCC[C@@](C)(O)C2)C(=O)c2cc(O)cc3cccc(C#C)c23)CC1

InChI Key InChIKey=FEJLUAZGBFPYKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 698925   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM698925((R)-(2-((1-((dimethyl- amino)methyl)cyclo- propyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM698925((R)-(2-((1-((dimethyl- amino)methyl)cyclo- propyl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetGTPase KRas [G12V]/Son of sevenless homolog 1 [564-1049](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM698925((R)-(2-((1-((dimethyl- amino)methyl)cyclo- propyl)...)
Affinity DataIC50: 2.00E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent