BDBM698932 (2-(((R)-1-((dimethyl- amino)methyl)-2,2- difluorocyclo- propyl)methoxy)-4-((R)-3- hydroxy-3-methylpiperidin- 1-yl)-5,7-dihydro- 6H-pyrrolo[3,4-d]pyrimidin- 6-yl)(8-ethynyl-3- hydroxynaphthalen-1- yl)methanone::US20240317759, Example 141

SMILES CN(C)CC1(COc2nc3CN(Cc3c(n2)N2CCC[C@@](C)(O)C2)C(=O)c2cc(O)cc3cccc(C#C)c23)CC1(F)F

InChI Key InChIKey=XWQMHKOFBSHRJQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 698932   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM698932((2-(((R)-1-((dimethyl- amino)methyl)-2,2- difluoro...)
Affinity DataIC50: 500nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetGTPase KRas [G12V]/Son of sevenless homolog 1 [564-1049](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM698932((2-(((R)-1-((dimethyl- amino)methyl)-2,2- difluoro...)
Affinity DataIC50: 900nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM698932((2-(((R)-1-((dimethyl- amino)methyl)-2,2- difluoro...)
Affinity DataIC50: 1.30E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent