BDBM698942 (R)-1-(2-(((2R,7aS)-2-fluorotetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)-7-(6-methyl-5- (trifluoromethyl)-1H-indazol-4-yl)-5,6,7,8- tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3- methylpiperidin-3-ol::US20240317759, Example 151

SMILES COc1nc(NC(=O)Cc2ccc(Cl)cc2COCc2ccccc2)ccc1C[C@H]1COC(=O)N1

InChI Key InChIKey=VZYMBJMMSBRQIS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 698942   

TargetDNA polymerase(HHV-5)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 698942BDBM698942(US12605369, Compound 2)
Affinity DataIC50: 108nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent