BDBM699288 2'-chloro-5'-methoxy-N-[6-(3- methoxyazetidin-1-yl)- [1,3]thiazolo[4,5-c]pyridin-2-yl]-6- methyl-[4,4'-bipyridine]-3-carboxamide::US20240327430, Example 129

SMILES COC1CN(C1)c1cc2sc(NC(=O)c3cnc(C)cc3-c3cc(Cl)ncc3OC)nc2cn1

InChI Key InChIKey=FXDITXOKAGLIJI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699288   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699288(2'-chloro-5'-methoxy-N-[6-(3- methoxyazetidin-1-yl...)
Affinity DataIC50: 100nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Polθ protein (P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2025
Entry Details
US Patent

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699288(2'-chloro-5'-methoxy-N-[6-(3- methoxyazetidin-1-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Pol&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent