BDBM699827 US20240335431, Example 8

SMILES CCN(C(C)C)C(=O)c1cc(F)ccc1-n1cc(C(=O)C2CN(C2)C(=O)[C@H]2N[C@@H]3CC[C@H]2C3)c2ccncc12

InChI Key InChIKey=MBEJBHVYGHBPLJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699827   

TargetMenin(Human)
Acerta Pharma

US Patent
LigandPNGBDBM699827(US20240335431, Example 8)
Affinity DataIC50: 27nMAssay Description:Compounds were tested in a biochemical binding assay using Menin protein at 2 nM (N6his-tev-Menin_4i80, PB-20-1459) and the substrate cRho110-Ahx-MBM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acerta Pharma

US Patent
LigandPNGBDBM699827(US20240335431, Example 8)
Affinity DataKi:  8.00E+3nMAssay Description:Cell membrane homogenates (60 μg protein) were incubated for 60 minutes at 22° C. with 2 nM [3H]AF-DX 384 in the absence or presence of the test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent