BDBM699888 2-(3-(1-((1S,2S,5R)-3-Azabicyclo[3.1.0-]hexane-2-carbonyl)-piperidine-4-carbonyl)-2-methyl-1H-pyrrolo[2,3-c]pyridin-1-yl)-5-fluoro-N-isopropyl-N-((R)-1,1,1-trifluoropropan-2-yl)benzamide (separated atropisomers)::US20240335431, Example 57-1

SMILES CC(C)N(C(C)C(F)(F)F)C(=O)c1cc(F)ccc1-n1c(C)c(C(=O)C2CCN(CC2)C(=O)[C@H]2NC[C@@H]3C[C@H]23)c2ccncc12

InChI Key InChIKey=YIOAUJAJDBBFRC-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699888   

TargetMenin(Human)
Acerta Pharma

US Patent
LigandPNGBDBM699888(2-(3-(1-((1S,2S,5R)-3-Azabicyclo[3.1.0-]hexane-2-c...)
Affinity DataIC50: 33nMAssay Description:Compounds were tested in a biochemical binding assay using Menin protein at 2 nM (N6his-tev-Menin_4i80, PB-20-1459) and the substrate cRho110-Ahx-MBM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Acerta Pharma

US Patent
LigandPNGBDBM699888(2-(3-(1-((1S,2S,5R)-3-Azabicyclo[3.1.0-]hexane-2-c...)
Affinity DataKi: >1.00E+5nMAssay Description:Cell membrane homogenates (60 μg protein) were incubated for 60 minutes at 22° C. with 2 nM [3H]AF-DX 384 in the absence or presence of the test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent