BDBM700305 Preparation of trans-1-(6-((4-t-butylphenyl)amino)pyrimidin-4-yl)-4-(3,4-dihydroisoquinolin-2(1H)-yl)piperidin-3-ol::US20240336593, Example 39

SMILES CC(C)(C)c1ccc(Nc2cc(ncn2)N2CC[C@@H]([C@@H](O)C2)N2CCc3ccccc3C2)cc1

InChI Key InChIKey=HKKGINOGILGZCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 700305   

TargetProtein arginine N-methyltransferase 5(Human)
Lnnovstonetherapeutics

US Patent
LigandPNGBDBM700305(US20240336593, Example 39 | Preparation of trans-1...)
Affinity DataIC50: 100nMAssay Description:Test method: A 1× enzyme reaction buffer (10 mM Tris 8.0 (Sigma, Cat. No. T2694-1L), 0.01% Tween-20 (Sigma, Cat. No. P2287-100 ML), 1 mM DTT (Sigma, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
US Patent