BDBM702003 US12129258, Example 25

SMILES C[C@H]1Nc2ccn3ncc(c3n2)C(=O)OCCSc2ccc(F)cc21

InChI Key InChIKey=PWCNVYNJXOVGLO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 702003   

TargetNT-3 growth factor receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM702003(US12129258, Example 25)
Affinity DataIC50: 1.10nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM702003(US12129258, Example 25)
Affinity DataIC50: 1.10nMAssay Description:Based on HTRF of Cisbio (Cisbio, Cat. 08-52) principle, TRKA and ALK-L1196M kinase activity detection platform were established to determine the inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM702003(US12129258, Example 25)
Affinity DataIC50: 1.20nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM702003(US12129258, Example 25)
Affinity DataIC50: 1.60nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent