BDBM702005 4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyrazin-2-yl)-6-(((R)-morpholin-2-yl)methoxy))pyrazolo[1,5-a]pyridine-3-carbonitrile::US12129266, Example 9

SMILES [2H]C([2H])([2H])Oc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OC[C@H]5CNCCO5)cn5ncc(C#N)c45)cn2)C3)cn1

InChI Key InChIKey=GHVPABBEIJWMIH-FIBGUPNXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 702005   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702005(4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 0.370nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702005(4-(5-(6-((6-(methoxy-d3)pyridin-3-yl)methyl)-3,6-d...)
Affinity DataIC50: 4.30nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent