BDBM702009 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy-d3)pyridin-3-yl)methyl-d2)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile::US12129266, Example 13

SMILES [2H]C([2H])([2H])Oc1ccc(C([2H])([2H])N2C3CC2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1

InChI Key InChIKey=XIIOFHFUYBLOLW-RTSMIVPTSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 702009   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702009(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 0.0600nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM702009(6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-(methoxy...)
Affinity DataIC50: 0.270nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
Go to US Patent