BDBM702157 US20240360134, Example 119

SMILES C[C@H]1CCCN1CCNC(=O)c5ccc(F)c(Nc3nn(C)c4nc(Nc2cnn(C)c2)ncc34)c5

InChI Key InChIKey=WQALFYABUKYCQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 702157   

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM702157(US20240360134, Example 119)
Affinity DataIC50: 0.130nMAssay Description:Assay in white ProxiPlate 384-wellStep 1. Dispensing inhibitors/DMSO and low control: Using the ECHO 555 acoustic dispenser, spot desired compound se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM702157(US20240360134, Example 119)
Affinity DataIC50: 1.40nMAssay Description:Step 1. Dispensing inhibitors: Using Echo, dispense 40 nL/well (or less) compound serial dilutions in DMSO onto the assay plate.Step 2. Dispensing Ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM702157(US20240360134, Example 119)
Affinity DataIC50: 6.60E+3nMAssay Description:Step 1. Dispensing inhibitors/controls: Using Echo, dispense 10 nL/well compound serial dilutions in DMSO to columns 1-22 (in 384-well plates) or col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent