BDBM702631 US20240360154, Compound Z177

SMILES COC[C@]1(C)Nc2c(cnc3[nH]cc(C(=O)c4ccc(Oc5c(OC)ccc(F)c5F)cc4Cl)c23)NC1=O

InChI Key InChIKey=GRUAYQGMSCGGDX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 702631   

TargetTyrosine-protein kinase BTK(Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM702631(US20240360154, Compound Z177)
Affinity DataIC50: 6.40nMAssay Description:A 3-fold gradient concentration stock solution of 1000× compound was prepared using DMSO and diluted 100-fold to 10× compound stock solution using re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Genfleet Therapeutics (Shanghai)

US Patent
LigandPNGBDBM702631(US20240360154, Compound Z177)
Affinity DataIC50: 11.1nMAssay Description:A 3-fold gradient concentration stock solution of 1000× compound was prepared using DMSO and diluted 100-fold to 10× compound stock solution using re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
US Patent