BDBM702774 US20240360157, Example 128

SMILES CN(C)c1cc(-c2cc3c(N4CC5CCC(C4)N5C(=O)[C@@H]4C[C@H]4F)ccnn3c2)ccn1

InChI Key InChIKey=CENFCEFROIFFFD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 702774   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702774(US20240360157, Example 128)
Affinity DataIC50: 2.90nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Biogen Ma

US Patent
LigandPNGBDBM702774(US20240360157, Example 128)
Affinity DataIC50: 29nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702774(US20240360157, Example 128)
Affinity DataIC50: 68nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [3-974](Human)
Biogen Ma

US Patent
LigandPNGBDBM702774(US20240360157, Example 128)
Affinity DataIC50: 844nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent