BDBM702867 (3-(6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)((1S,2R)-2-fluorocyclopropyl)methanone::US20240360157, Example 221

SMILES O=C([C@@H]1C[C@H]1F)N1C2CCC1CN(c1ncnc3[nH]c(-c4cnn(C(F)F)c4)cc13)C2

InChI Key InChIKey=PXALDOWLQORFBK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 702867   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702867((3-(6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7H-pyrr...)
Affinity DataIC50: 2.80nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702867((3-(6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7H-pyrr...)
Affinity DataIC50: 73nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Biogen Ma

US Patent
LigandPNGBDBM702867((3-(6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7H-pyrr...)
Affinity DataIC50: 82nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [3-974](Human)
Biogen Ma

US Patent
LigandPNGBDBM702867((3-(6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-7H-pyrr...)
Affinity DataIC50: 461nMAssay Description:The kinase activity of recombinantly generated catalytic kinase (also known as JH1) domain of human JAK1, JAK2, JAK3 and TYK2 were evaluated in a pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
US Patent