BDBM702923 US20240366581, Example 1

SMILES COc1cc2ncn(-c3ccc(C(N)=O)c(Oc4ccccc4Cl)n3)c2cc1OC

InChI Key InChIKey=DCDKXVMMAAIMRA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 702923   

TargetSerine/threonine-protein kinase SIK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM702923(US20240366581, Example 1)
Affinity DataIC50: 14.2nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM702923(US20240366581, Example 1)
Affinity DataIC50: 15.1nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM702923(US20240366581, Example 1)
Affinity DataIC50: 57.2nMAssay Description:In the presence of SIK2 (resp. SIK1 or SIK3) and ATP the CHK-peptide (KKKVSRSGLYRSPSMPENLNRPR with C-terminal arginine amide modification) were phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent