BDBM703900 4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- naphthyridin-2-amine. LCMS [M + 1]: 254.3. 1H NMR (400 MHz, MeOD) $#948; = 8.43 (d, J = 2.0 Hz, 1H), 7.68-7.63 (m, 1H), 7.47 (s, 1H), 7.36 (s, 1H), 6.87 (d, J = 0.8 Hz, 1H), 3.99 (s, 2H), 3.85 (s, 3H), 2.60 (d, J = 0.8) Hz, 3H).::US20240368153, Example 2-9

SMILES Cc1cc(N)nc2cc(Cc3cnn(C)c3)cnc12

InChI Key InChIKey=HXTWDDOCZAZLCT-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703900   

LigandPNGBDBM703900(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
Affinity DataIC50: 204nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703900(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
Affinity DataKd:  137nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
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LigandPNGBDBM703900(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
Affinity DataKd:  748nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703900(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
Affinity DataIC50: 1.71E+4nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703900(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
Affinity DataIC50: 2.43E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent