BDBM703921 N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl]pyrimidine-4-carboxamide. LCMS [M + 1]+ = 295.1. 1H NMR (400 MHz, DMSO-d6) $#948; = 14.68-14.08 (m, 1H), 9.92 (br t, J = 6.2 Hz, 1H), 9.48- 9.24 (m, 2H), 9.12 (d, J = 5.0 Hz, 1H), 8.80 (d, J = 2.0 Hz, 1H), 8.48-8.24 (m, 1H), 8.08-8.00 (m, 2H), 7.16 (d, J = 1.0 Hz, 1H), 4.68 (br d, J = 6.2 Hz, 2H), 2.64 (d, J = 0.8 Hz, 3H).::US20240368153, Example 7-2

SMILES Cc1cc(N)nc2cc(CNC(=O)c3ccncn3)cnc12

InChI Key InChIKey=ZQCGSAGDRXLPTI-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 703921   

LigandPNGBDBM703921(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 313nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703921(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  151nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703921(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataKd:  2.22E+3nMAssay Description:Table A2: In vivo biotinylated PRMT5-MEP50 was diluted to 4.5 μM in 25 mM Bicine pH 7.6, 100 mM NaCl, 1 mM TCEP, and 0.05% Tween-20 and injected at 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703921(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 2.20E+4nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM703921(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Table B1: The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent