BDBM703976 US20240368161, Compound 4

SMILES CCC(C#N)n1cc(-c2cccc3nc(NC(=O)C4CC4)cn23)cn1

InChI Key InChIKey=DFXZVFSXMKPHLH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 703976   

TargetTyrosine-protein kinase JAK2(Human)
Cgenetech (Suzhou, China)

US Patent
LigandPNGBDBM703976(US20240368161, Compound 4)
Affinity DataIC50: 4.68nMAssay Description:1) 4 μL of the 2.5× compound to be tested was added to an HTRF 96 well low volume plate, and then 2 μL of 5× substrate was added from one side of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Cgenetech (Suzhou, China)

US Patent
LigandPNGBDBM703976(US20240368161, Compound 4)
Affinity DataIC50: 19.5nMAssay Description:1) 4 μL of the 2.5× compound to be tested was added to an HTRF 96 well low volume plate, and then 2 μL of 5× substrate was added from one side of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cgenetech (Suzhou, China)

US Patent
LigandPNGBDBM703976(US20240368161, Compound 4)
Affinity DataIC50: 36.3nMAssay Description:1) 4 μL of the 2.5× compound to be tested was added to an HTRF 96 well low volume plate, and then 2 μL of 5× substrate was added from one side of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent