BDBM704437 6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamide::US20240374606, Example 1

SMILES Cn1cnc2c(-c3cnc(Nc4ccc(N5CCOCC5)cc4)c(C(N)=O)n3)cccc21

InChI Key InChIKey=AFUGKASDRSHPJZ-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 704437   

LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataIC50: 31nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues) expressed in Insect cell using LRRKtide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant GLK (1 to 380 residues) expressed in insect cells using LRRKtide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataIC50: 1.66E+3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant LCK expressed in insect cells using EQEDEDEPEGIYGVLE-amide as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataIC50: 5.14E+3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704437BDBM704437(6-(1-Methylbenzimidazol-4-yl)-3-(4-morpholinoanili...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of HPK1 in human CD3-positive T cell assessed as induction of IL-2 secretion pretreated for 1 hr followed by incubation with anti-CD3/anti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed