BDBM704438 5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamide::US20240374606, Example 2

SMILES Cc1nc(Nc2ccc(N3CCOCC3)cc2)c(C(N)=O)nc1-c1cccc2c1ncn2C

InChI Key InChIKey=BNESJBZBRJSCLR-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 704438   

LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 5nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues) expressed in Insect cell using LRRKtide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 158nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant GLK (1 to 380 residues) expressed in insect cells using LRRKtide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 158nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetLymphocyte cytosolic protein 2(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SLP76 phosphorylation in human T cells by alphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of HPK1 in human CD3-positive T cell assessed as induction of IL-2 secretion pretreated for 1 hr followed by incubation with anti-CD3/anti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 1.98E+4nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant LCK expressed in insect cells using EQEDEDEPEGIYGVLE-amide as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed