BDBM704919 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (2-4-cyclohexyl-2-(2- isopropylphenyl)piperazin-1-yl)-7- azaspiro[3.5]nonan-7-yl)-N-((4-((((1r,4r)-4- hydroxy-4- methylcyclohexyl)methyl)amino)-3- nitrophenyl)sulfony])benzamide::US20240376097, Example 9

SMILES CC(C)c1ccccc1C1CN(C2CCCCC2)CCN1C1CC2(CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NC[C@H]5CC[C@](C)(O)CC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)C1

InChI Key InChIKey=DBEDMQWCBNSMBD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 704919   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM704919(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (2-4-cyc...)
Affinity DataIC50: 0.0340nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM704919(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (2-4-cyc...)
Affinity DataIC50: 0.520nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2-G101V protein with its ligand in an assay based on time-resolved fluorescence resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent