BDBM705295 (R)-1-(5-amino-3-(3-amino-3H-spiro[benzofuran-2,4'-piperidine]-1'-yl)-6-((2-chloro-3-(oxazole-2-yl)phenyl)sulfanyl)pyrazine-2-yl)ethanone ::US20240376119, Example 1

SMILES CC(=O)c3nc(Sc2cccc(c1ncco1)c2Cl)c(N)nc3N4CCC6(CC4)Oc5ccccc5[C@H]6N

InChI Key InChIKey=KFHOSQBMLMZYEP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705295   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM705295((R)-1-(5-amino-3-(3-amino-3H-spiro[benzofuran-2,4'...)
Affinity DataIC50: 20nMAssay Description:A mixed liquor of 2× working SHP2 reagent (0.4 nM) and 0.5 μM SHP-2 activated peptide (BPS bioscience #79319-2) was prepared with 1× enzyme buffer. A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent