BDBM705298 (R)-5-amino-3-(3-amino-3H-spiro[benzofuran-2,4'-piperidine]-1'-yl)-6-((2-chloro-3-(oxazole-2-yl)phenyl)sulfanyl)pyrazine-2-carboxylic acid methyl ester ::US20240376119, Example 16

SMILES COC(=O)c1nc(Sc2cccc(-c3ncco3)c2Cl)c(N)nc1N1CCC2(CC1)Oc1ccccc1[C@H]2N

InChI Key InChIKey=RMCYQZGXLNRXNF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705298   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM705298((R)-5-amino-3-(3-amino-3H-spiro[benzofuran-2,4'-pi...)
Affinity DataIC50: 20nMAssay Description:A mixed liquor of 2× working SHP2 reagent (0.4 nM) and 0.5 μM SHP-2 activated peptide (BPS bioscience #79319-2) was prepared with 1× enzyme buffer. A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent