BDBM705300 (R)-1'-(6-amino-5-((2-chloro-3-(oxazole-2-yl)phenyl)sulfanyl)-3-(oxetane-3-yl)pyrazine-2-yl)-3H-spiro[benzofuran-2,4'-piperidine]-3-amine ::US20240376119, Example 21

SMILES Nc1nc(N2CCC3(CC2)Oc2ccccc2[C@H]3N)c(C2COC2)nc1Sc1cccc(-c2ncco2)c1Cl

InChI Key InChIKey=MFBNDVKLFLWGDQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705300   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM705300((R)-1'-(6-amino-5-((2-chloro-3-(oxazole-2-yl)pheny...)
Affinity DataIC50: 20nMAssay Description:A mixed liquor of 2× working SHP2 reagent (0.4 nM) and 0.5 μM SHP-2 activated peptide (BPS bioscience #79319-2) was prepared with 1× enzyme buffer. A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent