BDBM705304 (R)-1-(5-amino-6-((2-amino-3-chloropyridine-4-yl)sulfanyl)-3-(3-amino-3-deuterium-spiro[benzofuran-2,4'-piperidine]-1'-yl)pyrazine-2-yl)ethanone ::US20240376119, Example 56

SMILES [2H][C@@]1(N)c2ccccc2OC12CCN(c1nc(N)c(Sc3ccnc(N)c3C)nc1C(C)=O)CC2

InChI Key InChIKey=RXNPZNVBPGPVRO-YUIGOLOMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705304   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM705304((R)-1-(5-amino-6-((2-amino-3-chloropyridine-4-yl)s...)
Affinity DataIC50: 20nMAssay Description:A mixed liquor of 2× working SHP2 reagent (0.4 nM) and 0.5 μM SHP-2 activated peptide (BPS bioscience #79319-2) was prepared with 1× enzyme buffer. A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent