BDBM705631 (E)-3-((1R,5S,6S)-3-amino-5-(5-(5-chloropicolinamido)-2-fluorophenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)acrylic acid::US20160046618, Example 757

SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)[C@@H]2C[C@]2(/C=C/C(=O)O)S1

InChI Key InChIKey=OYXIUAQOEKOTSE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 705631   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705631((E)-3-((1R,5S,6S)-3-amino-5-(5-(5-chloropicolinami...)
Affinity DataIC50: 0.176nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM705631((E)-3-((1R,5S,6S)-3-amino-5-(5-(5-chloropicolinami...)
Affinity DataIC50: 2.03nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM705631((E)-3-((1R,5S,6S)-3-amino-5-(5-(5-chloropicolinami...)
Affinity DataIC50: 4.58E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent