BDBM706409 US20240383900, Compound PPA-073

SMILES F[C@@H]1CNC[C@H]1Oc1cc(NCc2ccc(-c3ccccn3)cc2)n2ncc(C3CC3)c2n1

InChI Key InChIKey=VXPOWGZNPZRARA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 706409   

TargetCyclin-dependent kinase 12(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM706409(US20240383900, Compound PPA-073)
Affinity DataIC50: 33nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 7(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM706409(US20240383900, Compound PPA-073)
Affinity DataIC50: 529nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent