BDBM706539 US20240383915, Example 78

SMILES Cc1cc(N)nc(-c2c(Cl)c3c4c(nc(OCCc5nccn5C)nc4c2F)N([C@H](C)c2cccnc2N)CCO3)c1C(F)(F)F

InChI Key InChIKey=CNDIHYDZDLXHGO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 706539   

TargetGTPase KRas [G12V](Human)
Genentech

US Patent
LigandPNGBDBM706539(US20240383915, Example 78)
Affinity DataIC50: 0.0600nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM706539(US20240383915, Example 78)
Affinity DataIC50: 0.209nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent