BDBM706758 6-((1s,4s)-4-(1-methyl-3- (trifluoromethyl)-1H-pyrazol-5- yl)cyclohexyl)-2-thia-6- azaspiro[3.4]octane 2,2-dioxide::US20240398781, Example 2A

SMILES Cn1nc(C(F)(F)F)cc1[C@H]1CC[C@@H](N2CCC3(C2)CS(=O)(=O)C3)CC1

InChI Key InChIKey=AXBCAZZTBOWILA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 706758   

LigandPNGBDBM706758(6-((1s,4s)-4-(1-methyl-3- (trifluoromethyl)-1H-pyr...)
Affinity DataKi:  20nMAssay Description:DHCR7: The radioligand binding assay was prepared by adding assay buffer diluted hEBP-DHCR7 membrane at 66.7 μg/ml×150 μl/well into the 96-well compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
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LigandPNGBDBM706758(6-((1s,4s)-4-(1-methyl-3- (trifluoromethyl)-1H-pyr...)
Affinity DataKi:  44.5nMAssay Description:SPA: Determination of equilibrium dissociation constant Kd of radioligand: Membrane prepared as described above was pre-incubated with PVT-WGA SPA be...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent