BDBM707373 2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluoromethyl)-4- pyrimidinyl}-1-pyrazolyl)-1-(1- piperazinyl)-1-ethanone::US20240409530, Compound A7

SMILES C[C@H]1CCN1c1nc(-c2cnn(CC(=O)N3CCNCC3)c2)cc(C(F)F)n1

InChI Key InChIKey=DQHZSKGFDAEGAU-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 707373   

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandPNGBDBM707373(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluorome...)
Affinity DataIC50: 46nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetKetohexokinase(Rat)
Centennial Therapeutics

US Patent
LigandPNGBDBM707373(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluorome...)
Affinity DataIC50: 120nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707373(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluorome...)
Affinity DataIC50: 160nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetKetohexokinase(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707373(2-(4-{2-[(S)-2-methyl-1- azetidinyl]-6-(difluorome...)
Affinity DataIC50: 231nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent