BDBM707375 (2S,3R)-1-{6-(difluoromethyl)-4- [1-(1-methyl-3-azetidinyl)-4- pyrazolyl]-2-pyrimidinyl}-2- methyl-3-azetidinol::US20240409530, Compound A9

SMILES C[C@H]1[C@H](O)CN1c1nc(-c2cnn(C3CN(C)C3)c2)cc(C(F)F)n1

InChI Key InChIKey=FWXWCBVRUPYQSD-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 707375   

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandPNGBDBM707375((2S,3R)-1-{6-(difluoromethyl)-4- [1-(1-methyl-3-az...)
Affinity DataIC50: 10nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707375((2S,3R)-1-{6-(difluoromethyl)-4- [1-(1-methyl-3-az...)
Affinity DataIC50: 22nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetKetohexokinase(Rat)
Centennial Therapeutics

US Patent
LigandPNGBDBM707375((2S,3R)-1-{6-(difluoromethyl)-4- [1-(1-methyl-3-az...)
Affinity DataIC50: 37nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetKetohexokinase(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707375((2S,3R)-1-{6-(difluoromethyl)-4- [1-(1-methyl-3-az...)
Affinity DataIC50: 40.5nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent