BDBM707516 US20240409609, Compound 41

SMILES CC(C)c1ccc(N2CC(CS(C)(=O)=O)C2)c2cnc(Nc3ccnc(C#Cc4cccc(O)c4C=O)n3)cc12

InChI Key InChIKey=VSFJMYTYSXHPTH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 707516   

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707516(US20240409609, Compound 41)
Affinity DataIC50: 1.51nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707516(US20240409609, Compound 41)
Affinity DataIC50: 7.85nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707516(US20240409609, Compound 41)
Affinity DataIC50: 22.2nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent