BDBM707539 US20240409609, Compound 65

SMILES CC(C)Cn1/c(=N/C(=O)c2ccnc(Oc3cccc(O)c3C=O)c2)[nH]c2ccc(CN3CCN(C)CC3)cc21

InChI Key InChIKey=GDPHDNYHRAZVHU-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 707539   

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707539(US20240409609, Compound 65)
Affinity DataIC50: 0.616nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707539(US20240409609, Compound 65)
Affinity DataIC50: 1.59nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707539(US20240409609, Compound 65)
Affinity DataIC50: 10.1nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent