BDBM707646 US12168007, Ref. Ex. 2

SMILES CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1

InChI Key InChIKey=KPWSJANDNDDRMB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 707646   

TargetD(3) dopamine receptor(Human)
Richter Gedeon

US Patent
LigandPNGBDBM707646(US12168007, Ref. Ex. 2)
Affinity DataKi:  0.158nMAssay Description:Table 8: CHO-K1 cells expressing human recombinant D3 receptors were washed with PBS. Cells were scraped from the plates and centrifuged at 1000×g. C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/28/2025
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
Richter Gedeon

US Patent
LigandPNGBDBM707646(US12168007, Ref. Ex. 2)
Affinity DataKi:  0.309nMAssay Description:Table 7: Cell cultures (CHO-K1) expressing recombinant human D3 receptors (DRD3, GenBank ID U32499, purchased from Euroscreen Fast, Brussels, BE) wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/28/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Richter Gedeon

US Patent
LigandPNGBDBM707646(US12168007, Ref. Ex. 2)
Affinity DataKi:  0.631nMAssay Description:Table 4: CHO-K1 cells expressing human recombinant D2L receptors were washed with phosphate-buffered saline (PBS). Cells were scraped from the plates...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/28/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Richter Gedeon

US Patent
LigandPNGBDBM707646(US12168007, Ref. Ex. 2)
Affinity DataKi:  1.95nMAssay Description:Table 3: Cultured CHO-K1 cells expressing recombinant human D2L receptors (DRD2L cAMP Hunter™, Gi cell line, Eurofins DiscoverX, Fremont, CA, USA) we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/28/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Richter Gedeon

US Patent
LigandPNGBDBM707646(US12168007, Ref. Ex. 2)
Affinity DataKi:  29.5nMAssay Description:Table 11: Receptor membranes were prepared from the CHO-K1 recombinant AequoScreen® cell line stably expressing the human 5-HT2A receptor (PerkinElme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/28/2025
Entry Details
US Patent