BDBM709012 (S)-1-(6-(1H-pyrazol-1- yl)pyridin-2-y1)-7''-(3,5- difluorophenyl)dihydro- 1''H,3''H,5''H- spiro[piperidine-4,2''- pyrazolo[1,2-a]pyrazol]-1''- one::US20240425524, Example 2.14

SMILES O=C1N2[C@H](c3cc(F)cc(F)c3)CCN2CC12CCN(c1cccc(-n3cccn3)n1)CC2

InChI Key InChIKey=PQJLAPSPOALHBZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 709012   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM709012((S)-1-(6-(1H-pyrazol-1- yl)pyridin-2-y1)-7'-(3,5- ...)
Affinity DataEC50:  11nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution: top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM709012((S)-1-(6-(1H-pyrazol-1- yl)pyridin-2-y1)-7'-(3,5- ...)
Affinity DataEC50:  190nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution: top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent