BDBM709044 (S)-1-(3-chloro-5- fluorobenzoyl)-7''-(3,5- difluorophenyl) dihydro-1''H,3''H,5''H- spiro[piperidine-4,2''- pyrazolo[1,2- a]pyrazol]-l''-one::US20240425524, Example 4.19

SMILES O=C(c1cc(F)cc(Cl)c1)N1CCC2(CC1)CN1CC[C@@H](c3cc(F)cc(F)c3)N1C2=O

InChI Key InChIKey=ZJRCFAPSSITNAK-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 709044   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM709044((S)-1-(3-chloro-5- fluorobenzoyl)-7'-(3,5- difluor...)
Affinity DataEC50:  18nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution: top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent