BDBM709667 2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]ethyl}-6-methoxy-3,4-dihydro-2,7-naphthyridin-1(2H)-one::US12180213, Example 2

SMILES COc5cnc4C(=O)N(CCN3CCN(c1nsc2ccccc12)CC3)CCc4c5

InChI Key InChIKey=BZPQHANIFQTYHQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 709667   

Target5-hydroxytryptamine receptor 1A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM709667(2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  0.0300nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM709667(2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  0.460nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM709667(2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...)
Affinity DataKi:  128nMAssay Description:Binding inhibition rate for 5-HT1A receptor (%)=100−100×{(Binding amount of [3H]8-OH-DPAT in the presence of test compound)}−(Binding amount of [3H]8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent