BDBM710962 4-chloro-2-(3-((S)-((1r,3S)-3- fluorocyclobutyl)(4-methyl-4H-1,2,4-triazol- 3-yl)methyl)phenyl)-6-(((1- methylcyclobutyl)amino)methyl)isoindolin- 1-one::US12187709, Compound 320

SMILES Cn1cnnc1[C@H](c1cccc(N2Cc3c(Cl)cc(CNC4(C)CCC4)cc3C2=O)c1)[C@H]1C[C@H](F)C1

InChI Key InChIKey=UJEQWHRLDYTMPE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710962   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710962(4-chloro-2-(3-((S)-((1r,3S)-3- fluorocyclobutyl)(4...)
Affinity DataKd:  0.400nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710962(4-chloro-2-(3-((S)-((1r,3S)-3- fluorocyclobutyl)(4...)
Affinity DataKd:  2.20nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM710962(4-chloro-2-(3-((S)-((1r,3S)-3- fluorocyclobutyl)(4...)
Affinity DataIC50: 5.60nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM710962(4-chloro-2-(3-((S)-((1r,3S)-3- fluorocyclobutyl)(4...)
Affinity DataIC50: 7.5nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent