BDBM710993 2-(3-((1r,3r)-1-(4-methyl-4H-1,2,4-triazol- 3-yl)-3- (trifluoromethoxy)cyclobutyl)phenyl)-6-(((1- methylcyclobutyl)amino)methyl)-4- (tifluoromethyl)isoindolin-1-one::US12187709, Compound 351

SMILES Cn1nnnc1[C@]1(c2cccc(N3Cc4c(cc(CNC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)C[C@@H](OC(F)(F)F)C1

InChI Key InChIKey=MWELGVLXXIZJCE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710993   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710993BDBM710993(2-(3-((1r,3r)-1-(4-methyl-4H-1,2,4-triazol- 3-yl)-...)
Affinity DataKd:  1.20nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710993BDBM710993(2-(3-((1r,3r)-1-(4-methyl-4H-1,2,4-triazol- 3-yl)-...)
Affinity DataIC50: 6.40nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710993BDBM710993(2-(3-((1r,3r)-1-(4-methyl-4H-1,2,4-triazol- 3-yl)-...)
Affinity DataKd:  19nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710993BDBM710993(2-(3-((1r,3r)-1-(4-methyl-4H-1,2,4-triazol- 3-yl)-...)
Affinity DataIC50: 20nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent