BDBM711483 2-(4-Fluorophenyl)-1-[7-methyl-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3''-pyrrolidin]-1''-yl]ethan-1-one, ENT-1 (19) and 2-(4-Fluorophenyl)-1-[7-methyl-6-(1-methyl-1H-pyrazol-4-yl)-3, 4-dihydro-1H-spiro[1, 8-naphthyridine-2,3''-pyrrolidin]-1''-yl]ethan-1-one, ENT-2 (20)::US12187727, Example 20::US20250084084, Example 20

SMILES Cc1nc2c(cc1-c1cnn(C)c1)CC[C@]1(CCN(C(=O)Cc3ccc(F)cc3)C1)N2

InChI Key InChIKey=OPZFVSWLPKKDNC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 711483   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711483(2-(4-Fluorophenyl)-1-[7-methyl-6-(1-methyl-1H-pyra...)
Affinity DataKi:  0.600nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711483(2-(4-Fluorophenyl)-1-[7-methyl-6-(1-methyl-1H-pyra...)
Affinity DataKi:  0.600nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent