BDBM711513 2-(3,4-difluorophenyl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3''-pyrrolidin]-1''-yl]propan-1-one, DIAST-1::US12187727, Example 50::US20250084084, Example 51

SMILES Cc1nc2c(cc1-c1ncccn1)CC[C@@]1(CCN(C(=O)[C@H](C)c3ccc(F)c(F)c3)C1)N2

InChI Key InChIKey=KYIAQPMFQVLOOZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 711513   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711513(2-(3,4-difluorophenyl)-1-[(2S)-7-methyl-6-(pyrimid...)
Affinity DataKi:  0.810nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711513(2-(3,4-difluorophenyl)-1-[(2S)-7-methyl-6-(pyrimid...)
Affinity DataKi:  0.810nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711513(2-(3,4-difluorophenyl)-1-[(2S)-7-methyl-6-(pyrimid...)
Affinity DataKi:  120nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent