BDBM711592 2-[2-(difluoromethyl)-6-methoxypyrimidin-4-yl]-1-[(2S)-7-methyl-6-([1,2,4]triazolo[1,5-a]pyridin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3''-pyrrolidin]-1''-yl]propan-1-one, DIAST-1::US12187727, Example 129::US20250084084, Example 130

SMILES COc1cc([C@@H](C)C(=O)N2CC[C@@]3(CCc4cc(-c5nc6ccccn6n5)c(C)nc4N3)C2)nc(C(F)F)n1

InChI Key InChIKey=BOWAGGUOFLYKQH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 711592   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711592(2-[2-(difluoromethyl)-6-methoxypyrimidin-4-yl]-1-[...)
Affinity DataKi:  0.440nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711592(2-[2-(difluoromethyl)-6-methoxypyrimidin-4-yl]-1-[...)
Affinity DataKi:  0.440nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711592(2-[2-(difluoromethyl)-6-methoxypyrimidin-4-yl]-1-[...)
Affinity DataKi:  5.90nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent