BDBM711610 (2R)-1-[(2S)-6-(7,7-difluoro-6,7-dihydro-5H-pyrrolo[12-b][1,2,4]triazol-2-yl)-7-methyl-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3''-pyrrolidin]-1''-yl]-2-(5-fluoro-2-methoxypyridin-4-yl)propan-1-one::US12187727, Example 147::US20250084084, Example 147

SMILES COc1cc([C@@H](C)C(=O)N2CC[C@@]3(CCc4cc(-c5nc6n(n5)CCC6(F)F)c(C)nc4N3)C2)c(F)cn1

InChI Key InChIKey=MXHYZOFNIPNBCG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 711610   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711610((2R)-1-[(2S)-6-(7,7-difluoro-6,7-dihydro-5H-pyrrol...)
Affinity DataKi:  0.620nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711610((2R)-1-[(2S)-6-(7,7-difluoro-6,7-dihydro-5H-pyrrol...)
Affinity DataKi:  0.620nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent