BDBM711891 3-Methyl-N-(5-(3''-methyl-2''-oxo-2'',3''- dihydrospiro[cyclobutane-1,1''-pyrrolo[2,3- c]quinolin]-8''-yl)-2-(4-methylpiperazin- 1-yl)pyridin-3-yl)isothiazole-5- sulfonamide::US12187742, Example 246

SMILES Cc1cc(S(=O)(=O)Nc2cc(-c3ccc4ncc5c(c4c3)C3(CCC3)C(=O)N5C)cnc2N2CCN(C)CC2)sn1

InChI Key InChIKey=VMLHMYAEWYDPKR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 711891   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Xrad Therapeutics

US Patent
LigandPNGBDBM711891(3-Methyl-N-(5-(3'-methyl-2'-oxo-2',3'- dihydrospir...)
Affinity DataIC50: 0.5nMAssay Description:On day one, coat 96-well plate (ThermoFisher. Cat #: 442404) with GST-p53 (1-101) peptide (purified by Pharmaron, BCS department) by diluting 3 μg of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent