BDBM712739 US12195473, Compound 1-2

SMILES C=CC(=O)N1CCN(c2c(C#N)c(=O)n(-c3c(C)ccnc3C(C)C)c3nc(-c4c(N)c(F)c(F)c(F)c4F)c(Cl)cc23)CC1

InChI Key InChIKey=QRRJEUIQLZNPIO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 712739   

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM712739(US12195473, Compound 1-2)
Affinity DataIC50: 1.41nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent