BDBM712771 US12195473, Compound 12

SMILES C=CC(=O)N1CCN(c2c(C#N)c(=O)n(-c3c(C)ccnc3C(C)C)c3nc(-c4c(F)c(F)c(F)c(N)c4Cl)c(Cl)cc23)CC1

InChI Key InChIKey=YBBOCDTZZXTCAA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 712771   

TargetGTPase KRas(Human)
Jacobio Pharmaceuticals Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 712771BDBM712771(US12195473, Compound 12)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of His-tagged GDP-loaded KRAS G12C mutant (unknown origin) assessed as SOS1-mediated guanine nucleotide exchange preincubated with compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 712771BDBM712771(US12195473, Compound 12)
Affinity DataIC50: 3.85nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Jacobio Pharmaceuticals Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 712771BDBM712771(US12195473, Compound 12)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of His-tagged GDP-loaded KRAS G12C mutant (unknown origin) assessed as SOS1-mediated guanine nucleotide exchange preincubated with compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed