BDBM713287 (Method 11):(E)-1-((3S,4S)-3-((7-(7, 8-difluoronaphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)(methyl)amino)-4-fluoropyrrolidin-1-yl)-3-((R)-1-methylazetidin-2-yl)prop-2-en-1-one::US20250019387, Example 199

SMILES CN1CC[C@@H]1/C=C/C(=O)N1C[C@H](F)[C@@H](N(C)c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(-c4cccc5ccc(F)c(F)c45)ncc23)C1

InChI Key InChIKey=JHLRUQJIQLBRRJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 713287   

LigandPNGBDBM713287((Method 11):(E)-1-((3S,4S)-3-((7-(7, 8-difluoronap...)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50s for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
5/27/2025
Entry Details
US Patent