BDBM713288 (Method 11-Master):(E)-1-((R)-3-((7-(8-ethynyl-7-fluoronaphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)(methyl)amino)pyrrolidin-1-yl)-3-((R)-1-methylazetidin-2-yl)prop-2-en-1-one::US20250019387, Example 200

SMILES C#Cc1c(F)ccc2cccc(-c3ncc4c(N(C)[C@@H]5CCN(C(=O)/C=C/[C@H]6CCN6C)C5)nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)c12

InChI Key InChIKey=VJKGEOVPKJGBAI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 713288   

LigandPNGBDBM713288((Method 11-Master):(E)-1-((R)-3-((7-(8-ethynyl-7-f...)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50s for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
5/27/2025
Entry Details
US Patent