BDBM713318 (Method 2):(E)-1-(3-(((7-(8-chloro-7-fluoronaphthalen-1-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)(methyl)amino)methyl)azetidin-1-yl)-3-(3-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-5-yl)prop-2-en-1-one::US20250019387, Example 229

SMILES CN(CC1CN(C(=O)/C=C/c2nc(C(C)(C)O)no2)C1)c1nc(OCC23CCCN2CCC3)nc2c(F)c(-c3cccc4ccc(F)c(Cl)c34)ncc12

InChI Key InChIKey=ZZFVDBWBCBDEPO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 713318   

LigandPNGBDBM713318((Method 2):(E)-1-(3-(((7-(8-chloro-7-fluoronaphtha...)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50s for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
5/27/2025
Entry Details
US Patent